Reactive oxygen species: The good, the bad, and the enigma
نویسنده
چکیده
Work carried out primarily in the laboratory of Fabrizio d'Adda di Fagagna unveils the mitogenic properties of Ras-induced reactive oxygen species (ROS) and their relationship with the DNA damage response. Combined data from studies of cultured cells, zebrafish models, and clinical material consistently support a role of the RAS-RAC1-NOX4 axis in ROS induction, hyperproliferation, and senescence.
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عنوان ژورنال:
دوره 1 شماره
صفحات -
تاریخ انتشار 2014